I was less impressed with Harmon’s previous “Bad Jews,” which while bristling with clever dialogue, was strident and built around a thoroughly obnoxious woman character who was hard to endure, even though her self-righteousness was part of the point. With “Significant Other” Harmon’s characters are easier to care about, although I do find lacking an absence of more than their self-involvement without talking about the world beyond or even shedding light on their working life. But I suppose that tight focus is also part of the point.

In any event the cast elevates interest in those they are portraying. Although all three women are extremely well depicted, the most flamboyant and play-stealing performance comes from Gideon Glick as Jordan Berman, whose unfulfilled longings and frustrations can break your heart. He is a jumble of nerves, hungering after a hunk of a man he desires, but who is out of reach. He struggles over how to behave, whether to send a candid email or not. But in truth Jordon is so frenetic and hysterical that a romantic candidate would be hard-pressed to deal with his emotions and neediness.

Glick has some powerful lines as Jordan. At a movie date watching a film about the Franco-Prussian war and seeing soldiers die, he wonders, “How many people in the history of the world died without getting what they want in life?” Also, after seeing all three women friends, one by one, getting married, Jordan gives a passionate, accusatory speech in which he attempts to express how he feels, declaring to the woman who has been his closest friend, “Your wedding is my funeral.” At the end of the play we are left with a portrait of Jordan in all his frustrated loneliness.

The women observed are very different from one another. Exuberant Kiki, brashly enacted by Sas Goldberg, is the first to get her man. At Kiki’s wedding, for which her friends go to Kentucky, the more sophisticated Vanessa, impressively played by Carra Patterson, meets a man to whom she is attracted, and she is next to the altar. The last to wed is warmhearted Lindsay Mendez as Laura, who has been very buddy-buddy with Jordan, and his still being without Mr. Right makes her wedding extra difficult for him to take. His tirade is really unfair to her, but he cannot help but explode into an outpouring of his anxieties and disappointments.

Luke Smith and John Behlmann show admirable versatility portraying the different men in the mélange, sometimes adding amusement to scenes.

The play is given an extra dimension with the character of Jordan’s grandmother, Helen, wonderfully played by veteran actress Barbara Barrie. Jordan visits her and they chat and go over family photographs together. A widow, she wistfully copes with her own lonely life and attempts to encourage Jordan, for whom she remains an anchor. It is a tender portrait of a character sensitively interpreted by Barrie in a life-affirming manner, even though she talks contrastingly of suicide but makes clear it is just idle talk, not anything she would do. The scenes of youth and age coalescing are heartwarming.

The imaginative staging is due much credit. Mark Wendland has designed a multi-area set that enables the cast to move freely. Director Cullman makes the most of the characters weaving in and out of time and place. For example, when Jordan is on his movie date, as he sits there he is making comments about his experience to his friends elsewhere on stage. This breaking of time frames gives the play creative fluidity.